Viagra for alzheimer's disease

Author: Abigailtiger | 2024-10-13 01:57:30

By the National Institute on Aging of the National Institutes of Health (NIH) under award numbers R01AG066707, U01AG073323, R01AG076448, R01AG082118, RF1AG082211, R01AG084250, R56AG074001, andR21AG083003, and the National Institute of Neurological Disorders and Stroke of NIH under award number RF1NS133812.CLEVELAND – New Cleveland Clinic-led research points to sildenafil (Viagra) as a potential treatment for Alzheimer's disease. The study provides evidence from computational models, insurance claims data and observations from brain cells in Alzheimer's patients.Sildenafil is the main component of drugs used to treat erectile dysfunction (Viagra) and pulmonary arterial hypertension (Revatio)."Our findings provide further weight to re-purposing this existing FDA-approved drug as a novel treatment for Alzheimer's, which is in great need of new therapies," said Feixiong Cheng, Ph.D., who led the research. "We used artificial intelligence to integrate data across multiple domains which all indicated sildenafil's potential against this devastating neurological disease."Alzheimer's disease currently affects over 6 million Americans and incidence is expected to triple by 2050, underscoring the need for rapid development of new prevention and treatment strategies. Drug repurposing – use of an existing drug for new therapeutic purposes – offers a practical alternative to the costly and time-consuming traditional drug discovery process.Published in Journal of Alzheimer's Disease, the study builds upon the researchers' earlier findings in 2021 that used computational models to initially identify sildenafil as a promising drug candidate to help prevent and treat Alzheimer's disease.In the new study, Dr. Cheng, director of the Cleveland Clinic Genome Center, and his team analyzed millions of de-identified insurance claims from two independent patient databases, which revealed a 30-54% reduced prevalence in Alzheimer's disease diagnoses among patients who took sildenafil compared to those who did not after adjusting various possible confounding factors.In brain cells from Alzheimer's patients, researchers also showed that sildenafil lowers levels of neurotoxic tau proteins, which are known to be associated with Alzheimer's disease when they build up. They also found that neurons treated with sildenafil expressed genes related to cell growth, improved brain function, reduced inflammation and other processes known to protect against the neural degeneration associated with Alzheimer's disease.Dr. Cheng's findings demonstrate the feasibility of using computer models to identify potential new drug candidates in a fast, reliable way, representing a significant step forward in Alzheimer's drug discovery."After integrating this large amount of data computationally, it is rewarding to see sildenafil's effects in human neurons and real-world patient outcomes," said Dr. Cheng. "We believe our findings provide the evidence needed for clinical trials to further examine the potential effectiveness of sildenafil in patients with Alzheimer's disease."Dr. Cheng's co-authors include Andrew A. Pieper, M.D., Ph.D., of Louis Stokes Cleveland VA Medical Center, Case Western Reserve University and University Hospitals Cleveland Medical Center; and Jeffrey Cummings,

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Alzheimer’s disease (AD) is the leading cause of degenerative dementia in the aging population. Emrich HM, Schneider U. Effect of sildenafil (Viagra) on cerebral blood flow velocity: A pilot study. Psychiatry Res. 2025;17–209. doi: 10.1016/s (03) . [Google Scholar] 49. Buerk DG, Ances BM, Greenberg JH, Detre JA The men's average age at diagnosis was 58. Over a median period of about five years after diagnosis, men who took any of the ED drugs known as PDE5 inhibitors sildenafil (Viagra), tadalafil (Cialis), vardenafil, and avanafil (Stendra) were less likely to have an Alzheimer's diagnosis than those who didn't take one of the drugs.

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Sildenafil - Wikipedia

Viagra for alzheimer's disease	Abigailtiger	Viagra playing new role in fight against Alzheimer's disease
Viagra (sildenafil) Generic Facts, Side Effects Dosage	(4.4 / 1437 reviews)	Published in Journal of Alzheimer’s Disease, the study builds upon the researchers’ earlier findings in 2025 that used computational models to initially identify sildenafil as a promising drug candidate to help prevent and treat Alzheimer’s disease. In the new study, Dr. Cheng, director of the Cleveland Clinic Genome Center, and his team analyzed millions of de
Erectile dysfunction drugs linked to reduced Alzheimer's risk	(4.1 / 1298 reviews)	Posted by u/Old-Entertainment325 - 1 vote and 1 comment

Sixty seconds on Viagra and Alzheimer's disease - PubMed

CLEVELAND – New Cleveland Clinic-led research points to sildenafil (Viagra) as a potential treatment for Alzheimer's disease. The study provides evidence from computational models, insurance claims data and observations from brain cells in Alzheimer's patients.Sildenafil is the main component of drugs used to treat erectile dysfunction (Viagra) and pulmonary arterial hypertension (Revatio)."Our findings provide further weight to re-purposing this existing FDA-approved drug as a novel treatment for Alzheimer's, which is in great need of new therapies," said Feixiong Cheng, Ph.D., who led the research. "We used artificial intelligence to integrate data across multiple domains which all indicated sildenafil's potential against this devastating neurological disease."Alzheimer's disease currently affects over 6 million Americans and incidence is expected to triple by 2050, underscoring the need for rapid development of new prevention and treatment strategies. Drug repurposing – use of an existing drug for new therapeutic purposes – offers a practical alternative to the costly and time-consuming traditional drug discovery process.Published in Journal of Alzheimer's Disease, the study builds upon the researchers' earlier findings in 2021 that used computational models to initially identify sildenafil as a promising drug candidate to help prevent and treat Alzheimer's disease.In the new study, Dr. Cheng, director of the Cleveland Clinic Genome Center, and his team analyzed millions of de-identified insurance claims from two independent patient databases, which revealed a 30-54% reduced prevalence in Alzheimer's disease diagnoses among patients who took sildenafil compared to those who did not after adjusting various possible confounding factors.In brain cells from Alzheimer's patients, researchers also showed that sildenafil lowers levels of neurotoxic tau proteins, which are known to be associated with Alzheimer's disease when they build up. They also found that neurons treated with sildenafil expressed genes related to cell growth, improved brain function, reduced inflammation and other processes known to protect against the neural degeneration associated with Alzheimer's disease.Dr. Cheng's findings demonstrate the feasibility of using computer models to identify potential new drug candidates in a fast, reliable way, representing a significant step forward in Alzheimer's drug discovery."After integrating this large amount of data computationally, it is rewarding to see sildenafil's effects in human neurons and real-world patient outcomes," said Dr. Cheng. "We believe our findings provide the evidence needed for clinical trials to further examine the potential effectiveness of sildenafil in patients with Alzheimer's disease."Dr. Cheng's co-authors include Andrew A. Pieper, M.D., Ph.D., of Louis Stokes Cleveland VA Medical Center, Case Western Reserve University and University Hospitals Cleveland Medical Center; and Jeffrey Cummings, M.D., Sc.D., director emeritus of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas.Dhruv Gohel, Ph.D., and Amit Gupta, Ph.D., postdoctoral research associates in Dr. Cheng's laboratory, are co-first authors. The study was primarily supported

Viagra identified as a potential treatment to reduce Alzheimer’s

New York, Dec 7 : US researchers have found that impotence pill Viagra may help prevent as well as treat Alzheimer's disease. Sildenafil, approved by the US Food and Drug Adminstration (FDA) for erectile dysfunction (Viagra), is associated with 69 per cent reduced incidence of Alzheimer's disease, according to the findings published in the journal Nature Aging. A team from Cleveland Clinic analysed a database of more than 7 million patients, and used computational methodology to screen and validate over 1,600 FDA-approved drugs as potential therapies for Alzheimer's. The buildup of beta amyloid and tau proteins in the brain leads to amyloid plaques and tau neurofibrillary tangles -- two hallmarks of Alzheimer's-related brain changes. The team pinpointed drugs that target both amyloid and tau as having higher scores compared to drugs that target just one or the other. "Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, presented as the best drug candidate," said Feixiong Cheng, from Cleveland Clinic's Genomic Medicine Institute. Further, the analysis included patients using comparator drugs that either were in an active Alzheimer's clinical trial (losartan or metformin) or were not yet reported as relevant to the disease (diltiazem or glimepiride).They found that sildenafil users were 69 per cent less likely to develop Alzheimer's disease than non-sildenafil users after 6 years of follow-up. Specifically, sildenafil had a 55 per cent reduced risk of the disease compared to losartan, 63 per cent compared to metformin, 65 per cent compared to diltiazem and 64 per cent compared to glimepiride."Notably, we found that sildenafil use reduced the likelihood of Alzheimer's in individuals with coronary artery disease, hypertension and Type-2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without," Cheng said. The researchers also developed an Alzheimer's patient-derived brain cell model using stem cells. In the model, they found that sildenafil increased brain cell growth and decreased hyperphosphorylation of tau proteins -- a hallmark which leads to neurofibrillary tangles --, offering biological insights into how sildenafil may influence disease-related brain changes."Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer's disease, we are now planning a mechanistic trial and a phase II randomised clinical trial to test causality and confirm sildenafil's clinical benefits for Alzheimer's patients," said Cheng. "We also foresee our approach being applied to other neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis, to accelerate the drug discovery process."

New Cleveland Clinic-led research points to sildenafil (Viagra) as a potential treatment for Alzheimer s disease. The study provides evidence from computational models, insurance claims data and observations from brain cells in Alzheimer s patients. VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if taken with certain other medicines. Do not take VIAGRA if you take any other medicines called nitrates. Nitrates are used to treat chest pain (angina). especially if your heart is already weak from a heart attack or heart disease. Ask your doctor if your heart is